Watch this video to find out how to export data from the classic Zetasizer Nano software. Three main methods shown in this software video are: 1. The successor to the highly successful Zetasizer Nano range, the Advance range offers particle size, particle charge (zeta potential) and molecular weight analysis as well as advances such as Adaptive Correlation, M3-PALS Zeta analysis, Constant Current Zeta mode and a deep learning data quality advice software.
Light scattering with the Zetasizer owes part of its success to the ease of use integral in its default DTS software. The intuitive windows environment lets you setup a measurement (either in “manual” or in “standard operating procedure” mode) and all that’s left is to press the big green Start button. Decades of experience with light scattering have allowed the development of the Zetasizer platform with built in expert knowledge. In fact, we designed the first digital correlator (the core piece enabling determination of the correlation function for dynamic light scattering) at Malvern [1]. Thus it goes without saying that there is a lot more power in the system than what meets the eye.
Optional research software features Zetasizer – optional
- The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano.
- Both size and -potential measurements were carried out on Zetasizer Nano ZS (Malvern Instruments, Malvern, UK) using the Zetasizer Software version 7.13 (Malvern Instruments, Malvern, UK). Liposome concentrations of 0.3 mg/mL in 10 mM HEPES were used for the analysis.
- The below instructions and configuration file are for Zetasizer software version 7.12 Please note this is a hidden folder and you may just have to enter the folder C: ProgramData Malvern Instruments Zetasizer directly into Windows Explorer to get there. Caution: overwriting the existing configuration file will overwrite any customized.
The default of many of these advanced settings and features is their most practical values. You can access the setting if willing to do so. Caution: Do not read beyond unless you already are or plan to deeply familiarize yourself with light scattering. OK, with the warning out of the way, here are but a few of the settings that you can access in the advanced research features
- Core-shell model to test the influence of refractive index in Mie scattering
- Logarithmic and linear correlator settings
- Mutliple narrow mode, CONTIN, discrete exponential fit settings
- Cumulant order, weighting, fit range
- Rayleigh-Gans Debye selection or Mie scattering (see FAQ-Mie-Equations)
- White Mangelsdorf theory, complex ionic dispersants
A more detailed description of these parameters and their settings can be found in the Zetasizer Nano Research Grade Software Features. Yet this is not meant for general use, and if unfamiliar with light scattering could lead to confusion. That’s why these features are not apparent when the standard software is opened.
Malvern Dls Zetasizer Software
How to try out the research software
Once again, this section is not something to confront an inexperienced novice light scatterer: There is a way to test out and experience these advanced research features within the Zetasizer software. For a trial access go to Tools –> Options –> Feature Keys This will generate a trial key specifically for your software installation. “The description expands to: These features allow greater control over many aspects of data acquisition and processing. For a 30-day trial enter the licence xxxxxxxxx”. Press the Install licence key button. Now close and restart the software, which will then show an enabled Features button in the far right software corner on the bottom. Simply click on it to show details for the particular feature key.
Final recommendation: even if you do decide to get and enable the research grade software features, we advise to make the standard desktop shortcut start without research mode. You can accomplish this with a shortcut where the target gets appended with the option -noresearch.
[1] Robert Pecora in Dynamic Light Scattering : Applications of Photon Correlation Spectroscopy, ed. R. Pecora, page 4, Plenum Press New York (1985) : “…The Pike group at Malvern designed the first commercial digital correlator…”
Previously
Malvern Zetasizer Software Download
- Get the latest Zetasizer DTS software (download for free)
- Complex titrations – variable dosing (zeta and size)
- Tips and Tricks for Nanoparticle Characterization (44 questions and answers)
- Polydispersity/pdi from several peaks in DLS
- Which size: intensity volume number ?